Journal
BIOTECHNOLOGY ADVANCES
Volume 31, Issue 8, Pages 1200-1223Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2013.02.009
Keywords
Escherichia coli; Metabolic engineering; Bioprocess; Biochemical product; Industrial platform
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Funding
- National Natural Science Foundation of China [21006039]
- Sino-South Africa Cooperation Program [2009DFA31300]
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In order to decrease carbon emissions and negative environmental impacts of various pollutants, more bulk and/or fine chemicals are produced by bioprocesses, replacing the traditional energy and fossil based intensive route. The Gram-negative rod-shaped bacterium, Escherichia coli has been studied extensively on a fundamental and applied level and has become a predominant host microorganism for industrial applications. Furthermore, metabolic engineering of E. coli for the enhanced biochemical production has been significantly promoted by the integrated use of recent developments in systems biology, synthetic biology and evolutionary engineering. In this review, we focus on recent efforts devoted to the use of genetically engineered E. coli as a sustainable platform for the production of industrially important biochemicals such as biofuels, organic acids, amino acids, sugar alcohols and biopolymers. In addition, representative secondary metabolites produced by E. coli will be systematically discussed and the successful strategies for strain improvements will be highlighted. Moreover, this review presents guidelines for future developments in the bin-based chemical production using E. coli as an industrial platform. (C) 2013 Elsevier Inc. All rights reserved.
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