Journal
BIOTECHNOLOGY ADVANCES
Volume 31, Issue 8, Pages 1585-1599Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2013.08.010
Keywords
Polymeric nanoparticles; Diagnostic applications; Optical detection; Fluorescence; Polymeric coatings; Multifunctional nanoparticles; Silica
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Funding
- Research Executive Agency (REA) of the European Union [PITN-GA-2010-264772]
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Nanotechnology is a powerful tool for use in diagnostic applications. For these purposes a variety of functional nanoparticles containing fluorescent labels, gold and quantum dots at their cores have been produced, with the aim of enhanced sensitivity and multiplexing capabilities. This work will review progress in the application of polymeric nanoparticles in optical diagnostics, both for in vitro and in vivo detection, together with a discussion of their biodistribution and biocompatibility. (C) 2013 Elsevier Inc. All rights reserved.
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