Journal
BIOTECHNOLOGY ADVANCES
Volume 31, Issue 5, Pages 744-751Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2012.11.006
Keywords
Stem cell; Biotechnology; Regenerative medicine; Tissue engineering
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Funding
- Hagey Family Endowed Fund in Stem Cell Research and Regenerative Medicine
- Armed Forces Institute of Regenerative Medicine (United States Department of Defense)
- National Institutes of Health [R01-DK074095, R01-EB005718, R01-AG025016]
- Oak Foundation
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Stem cells embody the tremendous potential of the human body to develop, grow, and repair throughout life. Understanding the biologic mechanisms that underlie stem cell-mediated tissue regeneration is key to harnessing this potential. Recent advances in molecular biology, genetic engineering, and material science have broadened our understanding of stem cells and helped bring them closer to widespread clinical application. Specifically, innovative approaches to optimize how stem cells are identified, isolated, grown, and utilized will help translate these advances into effective clinical therapies. Although there is growing interest in stem cells worldwide, this enthusiasm must be tempered by the fact that these treatments remain for the most part clinically unproven. Future challenges include refining the therapeutic manipulation of stem cells, validating these technologies in randomized clinical trials, and regulating the global expansion of regenerative stem cell therapies. (c) 2012 Elsevier Inc. All rights reserved.
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