Journal
BIOTECHNOLOGY ADVANCES
Volume 30, Issue 5, Pages 979-988Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2011.07.021
Keywords
Genome-scale metabolic model; Systems biology; Metabolic engineering; Computational algorithms; Evolution
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Funding
- EU [212766]
- European Research Council
- Chalmers Foundation
- Knut and Alice Wallenberg Foundation
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Since the first large-scale reconstruction of the Saccharomyces cerevisiae metabolic network 15 years ago the development of yeast metabolic models has progressed rapidly, resulting in no less than nine different yeast genome-scale metabolic models. Here we review the historical development of large-scale mathematical modeling of yeast metabolism and the growing scope and impact of applications of these models in four different areas: as guide for metabolic engineering and strain improvement, as a tool for biological interpretation and discovery, applications of novel computational framework and for evolutionary studies. (C) 2011 Elsevier Inc. All rights reserved.
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