Journal
BIOTECHNOLOGY ADVANCES
Volume 30, Issue 6, Pages 1516-1523Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2012.03.010
Keywords
Artemisinin; Biotransformation; Malaria; Plasmodium; Terpenes
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The fungal and bacterial transformation of terpenoids derived from plant essential oils, especially the sesquiterpenoid artemisinin from Artemisia annua, has produced several new candidate drugs for the treatment of malaria. Obtaining new derivatives of terpenoids, including artemisinin derivatives with increased antimalarial activity, is an important goal of research in microbial biotechnology and medicinal chemistry. Published by Elsevier Inc.
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