Journal
BIOTECHNOLOGY ADVANCES
Volume 29, Issue 3, Pages 351-364Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2011.01.007
Keywords
2,3-Butanediol; Strain improvement; Substrate alternation; Process development; Downstream processing; Derivatives
Categories
Funding
- National Natural Science Foundation of China [20606018, 20936002, 21006049]
- National Basic Research Program of China [2009CB724700, 2011CBA00802]
- National High Technology Research and Development Program of China [2006AA02Z244]
- Talent Summits of Jiangsu Province [2008-D-63]
- Fok Ying Tung Education Foundation [123014]
- Program for New Century Excellent Talents in University from the Ministry of Education of China [NCET-09-0157]
- Nanjing University of Technology [BSCX200808]
- China Postdoctoral Science Foundation [20100471328]
- Jiangsu Planned Projects for Postdoctoral Research Funds of China [1001015 C]
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2,3-Butanediol is a promising bulk chemical due to its extensive industry applications. The state-of-the-art nature of microbial 2,3-butanediol production is reviewed in this paper. Various strategies for efficient and economical microbial 2,3-butanediol production, including strain improvement, substrate alternation, and process development, are reviewed and compared with regard to their pros and cons. This review also summarizes value added derivatives of biologically produced 2,3-butanediol and different strategies for downstream processing. The future prospects of microbial 2,3-butanediol production are discussed in light of the current progress, challenges, and trends in this field. Guidelines for future studies are also proposed. Crown Copyright (C) 2011 Published by Elsevier Inc. All rights reserved.
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