Journal
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
Volume 315, Issue 5, Pages F1243-F1249Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajprenal.00082.2017
Keywords
protein/peptide tags; single molecule labeling; trafficking
Categories
Funding
- American Heart Association [16PRE27510032]
- National Institutes of Health [1R01DK107263 01A1]
- American Heart Association
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK107263] Funding Source: NIH RePORTER
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The ability to detect and track single molecules presents the advantage of visualizing the complex behavior of transmembrane proteins with a time and space resolution that would otherwise be lost with traditional labeling and biochemical techniques. Development of new imaging probes has provided a robust method to study their trafficking and surface dynamics. This mini-review focuses on the current technology available for single-molecule labeling of transmembrane proteins, their advantages, and limitations. We also discuss the application of these techniques to the study of renal transporter trafficking in light of recent research.
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