Journal
CEREBRAL CORTEX
Volume 28, Issue 8, Pages 2775-2785Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhx157
Keywords
atrophy; depression; memory; MRI; YKL-40
Categories
Funding
- National Association for Public Health's dementia research program, Norway
- Norwegian Research Council
- European Research Council
- Medical Student Research Program at the University of Oslo
- Innlandet Hospital Trust [150201]
- Knut and Alice Wallenberg Foundation
- Swedish Research Council [2013-2546, K2013-61X-14002-13-5]
- Torsten Soderberg Foundation at the Royal Swedish Academy of Sciences
Ask authors/readers for more resources
Sleep problems relate to brain changes in aging and disease, but the mechanisms are unknown. Studies suggest a relationship between beta-amyloid (A beta) accumulation and sleep, which is likely augmented by interactions with multiple variables. Here, we tested how different cerebrospinal fluid (CSF) biomarkers for brain pathophysiology, brain atrophy, memory function, and depressive symptoms predicted self-reported sleep patterns in 91 cognitively healthy older adults over a 3-year period. The results showed that CSF levels of total- and phosphorylated (P) tau, and YKL-40-a marker of neuroinflammation/astroglial activation-predicted poor sleep in A beta positive older adults. Interestingly, although brain atrophy was strongly predictive of poor sleep, the relationships between CSF biomarkers and sleep were completely independent of atrophy. A joint analysis showed that unique variance in sleep was explained by P-tau and the P-tau x A beta interaction, memory function, depressive symptoms, and brain atrophy. The results demonstrate that sleep relates to a range of different pathophysiological processes, underscoring the importance of understanding its impact on neurocognitive changes in aging and people with increased risk of Alzheimer's disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available