Journal
ENDOCRINOLOGY
Volume 159, Issue 12, Pages 3874-3884Publisher
OXFORD UNIV PRESS INC
DOI: 10.1210/en.2018-00672
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Funding
- Medical Research Council [MRC_MC_UU_12012/3, MRC_MC_UU_12012/5]
- Wellcome Trust [106262/Z/14/Z, 106263/Z/14/Z]
- MRC [MC_UU_12012/5, MC_UU_00014/5, MC_UU_12012/3, MC_UU_00014/3] Funding Source: UKRI
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Gut hormones produced by gastrointestinal enteroendocrine cells modulate key physiological processes including glucose homeostasis and food intake, making them potential therapeutic candidates to treat obesity and diabetes. Understanding the function of enteroendocrine cells and the molecular mechanisms driving hormone production is a key step toward mobilizing endogenous hormone reserves in the gut as a therapeutic strategy. In this review, we will discuss the variety of ex vivo and in vitro model systems driving this research and their contributions to our current understanding of nutrient-sensing mechanisms in enteroendocrine cells.
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