Journal
CEREBRAL CORTEX
Volume 28, Issue 5, Pages 1831-1845Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhx169
Keywords
interneuron; multineuronal response reliability; network synchrony; optogenetics; two-photon imaging
Categories
Funding
- NEI [DP1EY024503, R01EY011787]
- NIMH [R01MH101218, R01MH100561]
- Japan Science and Technology Agency, PRESTO
- Ministry of Education, Culture, Sports, Science and Technology, Japan [15K18341]
- US Army Research Laboratory
- US Army Research Office [W911NF-12-1-0594]
- Grants-in-Aid for Scientific Research [17K14945] Funding Source: KAKEN
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For efficient cortical processing, neural circuit dynamics must be spatially and temporally regulated with great precision. Although parvalbumin-positive (PV) interneurons can control network synchrony, it remains unclear how they contribute to spatio-temporal patterning of activity. We investigated this by optogenetic inactivation of PV cells with simultaneous two-photon Ca2+ imaging from populations of neurons in mouse visual cortex in vivo. For both spontaneous and visually evoked activity, PV interneuron inactivation decreased network synchrony. But, interestingly, the response reliability and spatial extent of coactive neuronal ensembles during visual stimulation were also disrupted by PV-cell suppression, which reduced the functional repertoire of ensembles. Thus, PV interneurons can control the spatio-temporal dynamics of multineuronal activity by functionally sculpting neuronal ensembles and making them more different from each other. In doing so, inhibitory circuits could help to orthogonalize multicellular patterns of activity, enabling neural circuits to more efficiently occupy a higher dimensional space of potential dynamics.
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