Journal
ENDOCRINOLOGY
Volume 159, Issue 3, Pages 1328-1338Publisher
OXFORD UNIV PRESS INC
DOI: 10.1210/en.2018-00039
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Funding
- National Institute of Neurologic Disorders and Stroke [NS077661, NS062158, NS18338, NS066179, NS082179]
- National Institute on Drug Abuse [DA035008, DA041808]
- National Natural Science Foundation of China [31330033, 91332124, 31461163001, 81671107, 31471112]
- Specialized Research Fund for the Doctoral Program of Higher Education and Research Grants Council Earmarked Research Grants [20130091140003]
- Jiangsu Natural Science Foundation [BK2011014]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM008322] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P30NS062158, R01NS082179, R21NS077661, K99NS066179, R00NS066179, R01NS018338] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA035008, R01DA041808] Funding Source: NIH RePORTER
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Estrogens affect cerebellar activity and cerebellum-based behaviors. Within the adult rodent cerebellum, the best-characterized action of estradiol is to enhance glutamatergic signaling. However, the mechanisms by which estradiol promotes glutamatergic neurotransmission remain unknown. Within the mouse cerebellum, we found that estrogen receptor activation of metabotropic glutamate receptor type 1a strongly enhances neurotransmission at the parallel fiber-Purkinje cell synapse. The blockade of local estrogen synthesis within the cerebellum results in a diminution of glutamatergic neurotransmission. Correspondingly, decreased estrogen availability via gonadectomy or blockade of aromatase activity negatively affects locomotor performance. These data indicate that locally derived, and not just gonad-derived, estrogens affect cerebellar physiology and function. In addition, estrogens were found to facilitate parallel fiber-Purkinje cell synaptic transmission in both sexes. As such, the actions of estradiol to support cerebellar neurotransmission and cerebellum-based behaviors might be fundamental to understanding the normal processing of activity within the cerebellar cortex.
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