Journal
NEUROPSYCHIATRIC DISEASE AND TREATMENT
Volume 14, Issue -, Pages 1991-1998Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/NDT.S168060
Keywords
major depressive disorder; resting-state fMRI; precuneus
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Funding
- National Natural Science Foundation of China [81471379]
- Postdoctoral Foundation of Shanxi Medical University
- Doctoral Foundation of Shanxi Medical University
- Doctoral Foundation of Shanxi Province
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Background: Major depressive disorder (MDD) is a leading psychiatric disorder that has a lack of biomarkers for a diagnosis. Purpose: The objective of this study was to examine the structural and functional change in the precuneus within first-episode drug naive patients with MDD. Methods: Thirty-two first episode drug-naive patients with MDD and thirty healthy controls (HCs) were recruited in this study; the structural MRI and IMRI data were collected using the 3.0 T Trio Siemens System. All the patients were interviewed using the HAMD-17. Results: The difference between gray matter volume within the two groups was not observed. Results indicated that the low-frequency fluctuations (ALFF), fractional ALFF (fALFF) and regional homogeneity values of the precuneus within first-episode drug-naive patients with MDD were lower than the HCs. In addition, the fALFF value of the MDD was negatively and statistically significantly correlated with the HAMD-17 total score (P<0.05). Conclusion: The current study found abnormal activity of the precuneus at resting state in first-episode drug-naive patients with MDD, indicating that activity within the precuneus may be a potential biomarker for the diagnosis of MDD.
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