Journal
BIOTECHNIQUES
Volume 44, Issue 5, Pages 667-+Publisher
FUTURE SCI LTD
DOI: 10.2144/000112791
Keywords
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Funding
- National Cancer Institute, National Institutes of Health [NO1-CO-12400]
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While definitely not a new technology, mass spectrometry (MS) has seen incredible growth over the past 25 Years. Mass spectrometry has rapidly evolved to the forefront of analytical techniques; its ability to analyze proteins is the major driving force in the field of proteomics, MS instrumentation has increased approximately 5-fold in sensitivity every three years. The level of performance that is achievable with MS today allows scientists to study proteins in ways that were inconceivable a quarter century ago. This review of the history of MS over the past 25 years is timely in that it encompasses two of the biggest developments, electrospray and matrix-assisted laser desorption/ionization (MALDI), which have enabled many of the uses of this technology today.
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