Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1421, Issue -, Pages 68-81Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2015.07.045
Keywords
Liquid chromatography detectors; Universal detectors; Aerosol-based detectors
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Aerosol-based detectors developed within the last few decades have increasingly addressed the need for sensitive, universal liquid chromatography detection in a wide variety of applications. Herein, we review the operating principles, instrumentation, analytical characteristics, and recent applications of the three general types of such detectors: evaporative light scattering detection (ELSD), condensation nucleation light scattering detection (CNLSD); commercially known as the nano-quantity analyte detector (NQAD), and charged aerosol detection (CAD). Included is a comparative evaluation of the operational and analytical characteristics of these detectors. (C) 2015 Elsevier B.V. All rights reserved.
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