Journal
ACS CHEMICAL NEUROSCIENCE
Volume 9, Issue 1, Pages 11-28Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acschemneuro.7b00388
Keywords
Precision medicine; pediatrics; neurooncology; review
Funding
- National Institutes of Health through UCLA Medical Scientist Training Program [T32 GM008042]
- Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA Training Program
- Hyundai Hope on Wheels Foundation
- Alex's Lemonade Stand Foundation for Pediatric Cancer Research
- David Geffen School of Medicine
- Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA
- NATIONAL CANCER INSTITUTE [P50CA211015] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM008042] Funding Source: NIH RePORTER
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Central nervous system tumors are the leading cause of cancer related death in children. Despite much progress in the field of pediatric neurooncology, modern combination treatment regimens often result in significant late effects, such as neurocognitive deficits, endocrine dysfunction, secondary malignancies, and a host of other chronic health problems. Precision medicine strategies applied to pediatric neurooncology target specific characteristics of individual patients' tumors to achieve maximal killing of neoplastic cells while minimizing unwanted adverse effects. Here, we review emerging trends and the current literature that have guided the development of new molecularly based classification schemas, promising diagnostic techniques, targeted therapies, and delivery platforms for the treatment of pediatric central nervous system tumors.
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