Journal
BIOSYSTEMS
Volume 114, Issue 3, Pages 227-237Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biosystems.2013.10.001
Keywords
Mathematical modeling; Diffusion; Porous scaffold; Oxygen uptake rate; Cell proliferation; Cell density
Categories
Funding
- EU project MAGISTER [NMP3-LA-2008-214685]
Ask authors/readers for more resources
The mathematical prediction of cell proliferation in porous scaffold still remains a challenge. The analysis of existing models and experimental data confirms a need for a new solution, which takes into account cells development on the scaffold pore walls as well as some additional parameters such as the pore size, cell density in cellular layers, the thickness of the growing cell layer and others. The simulations, presented below, are based on three main approaches. The first approach takes into account multilayer cell growth on the pore walls of the scaffold. The second approach is a simulation of cell proliferation in a discrete process as a continuous one. The third one is the representation of scaffold structure as a system of cylindrical channels. Oxygen (nutrient) mass transfer is realized inside these channels. The model, described below, proposes the new solution to time dependent description of cell proliferation in porous scaffold and optimized trophical conditions for tissue development. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available