Journal
BIOSYSTEMS
Volume 109, Issue 3, Pages 430-443Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biosystems.2012.06.002
Keywords
Cellular Potts Model; Agent-based model; Subcellular Element Model; Cellular Particle Dynamics; Viscoelastic Ellipsoid Model; Elastic sphere model
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Funding
- CNCSIS-UEFISCSU [ID_76/2010]
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One of the most important challenges of contemporary biology is understanding how cells assemble into tissues. The complexity of morphogenesis calls for computational tools able to identify the dominant mechanisms involved in shaping tissues. This narrative review presents individual-based computational models that proved useful in simulating phenomena of interest in tissue engineering (TE), a research field that aims to create tissue replacements in the laboratory. First, we briefly describe morphogenetic mechanisms. Then, we present several computational models of cellular and subcellular resolution, along with applications that illustrate their potential to address problems of TE. Finally, we analyze experiments that may be used to validate computational models of tissue constructs made of cohesive cells. Our analysis shows that the models available in the literature are not exploited to their full potential. We argue that, upon validation, a computational model can be used to optimize cell culture conditions and to design new experiments. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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