Journal
BIOSYSTEMS
Volume 105, Issue 3, Pages 238-242Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biosystems.2011.05.009
Keywords
Tripartite synapse; ATP; Firing frequency; Hysteresis
Categories
Funding
- Interdisciplinary Center for Scientific Computing
- International Graduiertenkolleg 710 (DFG)
- National Genome Research Network, German Federal Ministry of Education and Research (BMBF)
Ask authors/readers for more resources
Recent experimental studies strongly suggest the influence of glial purinergic transmission in the modulation of synaptic dynamics. By releasing adenosine triphosphate (ATP), which accumulates as adenosine, astrocytes tonically suppressed synaptic transmission. The delayed multi-step feedback of the glial ATP with the neuron suggests the existence of a discrete hysteresis phenomena. By integration of this hysteretic behavior into a delayed leaky integrate-and-fire model for the tripartite synapses, a significant sensitivity of the pre- and postsynaptic firing frequency patterns to the adenosine feedback-delays is observed that might be of importance for adenosine-related neurological deficits, such as sleep disorders. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available