Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1400, Issue -, Pages 40-46Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2015.04.045
Keywords
Fabrication; Chiral amino acid ionic liquid; Magnetic nanospheres; Centrifugal chiral chromatography; D- and L-Tryptophan
Funding
- National Natural Science Foundation of China (NSFC) [21075007]
- Program for New Century Excellent Talents in University [NCET-11-0563]
- Beijing Nova program interdisciplinary [Z141107001814114]
- Fundamental Research Funds for the Central Universities [YS1406]
- Special Fund for Agro-scientific Research in the Public Interest [200803022, 201103027]
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As the rapid development of nanotechnology, the magnetic nanospheres modified with special chiral selective ligands show a great potentiality in enantiomeric separation. In this study, magnetic nanospheres modified with task-specific chiral ionic liquid were designed for the separation of chiral amino acids. These modified magnetic nanospheres were effective in a direct chiral separation of five racemic amino acids (D- and L-cysteine, D- and L-arginine, D- and L-leucine, D- and L-glutamine and D- and L-tryptophan). Furthermore, a new online method for complete separation of the enantiomers via the magnetic nanospheres was established with centrifugal chiral chromatography using a spiral tube assembly mounted on a type-J coil planet centrifuge. One kind of chiral compounds, D- and L-tryptophan was resolved well using this method. These results demonstrated that the modified nanospheres display a good chiral recognition ability, and can be used as a potential material for chiral separation of various racemates. (C) 2015 Elsevier B.V. All rights reserved.
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