Journal
BIOSYSTEMS
Volume 97, Issue 2, Pages 134-139Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biosystems.2009.04.008
Keywords
Regulatory networks; Logical modelling; Dynamical simulation; Computational systems biology
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Funding
- French Ministry of Research and Technology
- EU FP6 (DIAMONDS STREP)
- FP7 (APOSYS )
- Belgian Science Policy Office (IAP BioMaGNet)
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Many important problems in cell biology require the consideration of dense nonlinear interactions between functional modules. The requirement of computer simulation for the understanding of cellular processes is now widely accepted, and a variety of modelling frameworks have been designed to meet this need. Here, we present a novel public release of the Gene Interaction Network simulation suite (GINsim), a software designed for the qualitative modelling and analysis of regulatory networks. The main functionalities of GINsim are illustrated through the analysis of a logical model for the core network controlling the fission yeast cell cycle. The last public release of GINsim (version 2.3), as well as development versions, can be downloaded from the dedicated website (http://gin.univ-mrs.fr/GINsim/), which further includes a model library, along with detailed tutorial and user manual. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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