Journal
NATURE IMMUNOLOGY
Volume 19, Issue 1, Pages 85-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41590-017-0001-2
Keywords
-
Categories
Funding
- Wellcome Trust [090532/Z/09/Z]
- MRC (MHU) [G1000729]
- MRC (MRC Disease Team Award) [4050189188]
- MRC (PhD studentship)
- MRC (Single Cell Award) [MR/M00919X/1]
- CRUK [C7893/A12796, C1163/A21762, CRUKDF0176-DK, C5255/A20758]
- Bloodwise [13001, 12019]
- Oxford Partnership Comprehensive Biomedical Research Centre (NIHR BRC Funding scheme)
- US National Institutes of Health [R01CA188055, U01HL099999]
- New York Stem Cell Foundation
- Leukemia and Lymphoma Society
- Austrian Science Fund (FWF)
- Austrian Science Fund (FWF) [J 3358] Funding Source: researchfish
- Medical Research Council [1581868, MC_PC_12009, MR/M00919X/1, G1000729, G1000801c, MC_UU_12009/11, 1514301, MC_U137961145, MC_UU_00016/9, MR/L008963/1, 1779543, MC_UU_12009/9] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0617-10056] Funding Source: researchfish
- NATIONAL CANCER INSTITUTE [R01CA188055] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [U01HL099999] Funding Source: NIH RePORTER
- MRC [MC_UU_12009/11, MC_UU_00016/9, MC_UU_12009/9, G1000729, MR/L008963/1, MR/M00919X/1, MC_U137961145] Funding Source: UKRI
Ask authors/readers for more resources
The hierarchy of human hemopoietic progenitor cells that produce lymphoid and granulocytic-monocytic (myeloid) lineages is unclear. Multiple progenitor populations produce lymphoid and myeloid cells, but they remain incompletely characterized. Here we demonstrated that lympho-myeloid progenitor populations in cord blood - lymphoid-primed multi-potential progenitors (LMPPs), granulocyte-macrophage progenitors (GMPs) and multi-lymphoid progenitors (MLPs) - were functionally and transcriptionally distinct and heterogeneous at the clonal level, with progenitors of many different functional potentials present. Although most progenitors had the potential to develop into only one mature cell type ('uni-lineage potential'), bi- and rarer multi-lineage progenitors were present among LMPPs, GMPs and MLPs. Those findings, coupled with single-cell expression analyses, suggest that a continuum of progenitors execute lymphoid and myeloid differentiation, rather than only uni-lineage progenitors' being present downstream of stem cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available