Journal
BIOSENSORS & BIOELECTRONICS
Volume 56, Issue -, Pages 204-209Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2014.01.023
Keywords
Glucose biosensor; High-aspect-ratio Au-Ni coaxial nanorod array; Immersion gold; High sensitivity
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Funding
- National Science Council of Taiwan [NSC-101-2212-E-005-022-MY3]
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An effective glucose biosensor requires a sufficient amount of GOx immobilizing on the electrode surface. An electrode of a 3D nanorod array, having a larger surface-to-volume ratio than a 2D nanostructure, can accommodate more GOx molecules to immobilize onto the surface of the nanorods. In this study, a highly sensitive Au-Ni coaxial nanorod array electrode fabricated through the integration of nano electroforming and immersion gold (IG) method for glucose detection was developed. The average diameter of the as-synthesized Ni nanorods and that of the Au-Ni nanorods were estimated to be 150 and 250 nm, respectively; both had a height of 30 The aspect ratio was 120. Compared to that of a flat Au electrode, the effective sensing area was enhanced by 79.8 folds. Actual glucose detections demonstrated that the proposed Au-Ni coaxial nanorod array electrode could operate in a linear range of 27.5 mu M-27.5 mM with a detection limit of 55 mu M and a very high sensitivity of 769.6 mu A mM(-1) cm(-2). Good selectivity of the proposed sensing device was verified by sequential injections of uric acid (UA) and ascorbic acid (AA). Long-term stability was examined through successive detections over a period of 30 days. (C) 2014 Elsevier B.V. All rights reserved.
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