Journal
BIOSENSORS & BIOELECTRONICS
Volume 52, Issue -, Pages 216-224Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2013.08.030
Keywords
Silicon nanowire; Biosensor; Surface functionalisation; Electron beam lithography; 8-hydroxydeoxyguanosine (8-OHdG); Electronic readout
Categories
Funding
- Engineering and Physical Science Research Council [EP/I00193X/1]
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In this article we present ultra-sensitive, silicon nanowire (SiNW)-based biosensor devices for the detection of disease biomarkers. An electrochemically induced functionalisation method has been employed to graft antibodies targeted against the prostate cancer risk biomarker 8-hydroxydeoxyguanosine (8-OHdG) to SiNW surfaces. The antibody-functionalised SiNW sensor has been used to detect binding of the 8-OHdG biomarker to the SiNW surface within seconds of exposure. Detection of 8-OHdG concentrations as low as 1 ng/ml (3.5 nM) has been demonstrated. The active device has been bonded to a disposable printed circuit which can be inserted into an electronic readout system as part of an integrated Point of Care (POC) diagnostic. The speed, sensitivity and ease of detection of biomarkers using SiNW sensors render them ideal for eventual POC diagnostics. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.
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