Journal
BIOSENSORS & BIOELECTRONICS
Volume 60, Issue -, Pages 299-304Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2014.04.038
Keywords
Silver ion; DNA-metal interaction; Kelvin probe force microscope; Surface potential; Single droplet
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Funding
- National Research Foundation of Korea (NRF) [NRF-2013-044213, ERC-2007-0056094, NRF-2013058102]
- Ministry of Science
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Nanotoxicity is receiving great importance due to its potential impact on human health and environment and due to rapid development in the field of nanoscale research and industry. Herein, we report the Kelvin probe force microscope (KPPM)-based nanotoxicity material detection using surface potential difference. In general, it is difficult to measure the size of ion (Ag+) using a conventional atomic force microscope (AFM) because of the limited resolution. In this study, we have demonstrated that KPFM is capable of ultra-sensitive detection of silver ion with silver specific DNA by a single droplet. Furthermore, the measured surface potentials for Ag+ and DNA binding enable the detection performance for a practical sample that is general drinking water. Remarkably, the KPFM based silver ion detection enables an insight into the coordination chemistry, which plays an important role in early detection of toxicity. This implies that KPFM based detection system opens a new avenue for water testing sensor. (C) 2014 Elsevier B.V. All rights reserved.
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