Journal
BIOSENSORS & BIOELECTRONICS
Volume 53, Issue -, Pages 214-219Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2013.09.062
Keywords
Competitive immunoassay; Bisphenol A detection; Label-free detection; Electrochemical immunosensor
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Funding
- China Scholarship Council (CSC)
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A label-free electrochemical immunosensor was developed by electropolymerization of N-(3-(4-(2-(4-hydroxyphenyl)propan-2-yl)phenoxy)propyl) 3-(5-hydroxy-1,4-dihydro-1,4-dioxonaphthalen-2(3)-yl)propionamide (JugBPA). By combination with an antibody directed to bisphenol A (alpha BPA), this conducting polymer-based biosensor can detect BPA directly with a limit of detection of 2 pg mL(-1). Square wave voltammetry shows that the polymer film presents a current decrease upon anti-BPA binding and an opposite current increase upon BPA addition in solution. This electrochemical immunosensor (E-assay) also shows high selectivity towards closely related compounds (bisphenol A dimethacrylate, and dibutyl phthalate). The E-assay concept described here could be a promising tool for simple, low-cost and reagentless on-site environmental monitoring. (C) 2013 Elsevier B.V. All rights reserved.
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