Journal
BIOSENSORS & BIOELECTRONICS
Volume 42, Issue -, Pages 12-16Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2012.10.008
Keywords
Bovine serum albumin; Colorimetric response; Point-of-care testing; Polydiacetylene; Sepsis; Superparamagnetic iron oxide
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Funding
- Natural Sciences and Engineering Research Council
- Waterloo Institute for Nanotechnology
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Polydiacetylenes are ideal sensing materials due to their ability to change color in response to external stimuli. Here we report a new colorimetric, magnetically separable biosensor using a diacetylene monomer modified with a hydrophilic lysine derivative and superparamagnetic iron oxide nanopartides. The particles demonstrated a distinct blue to red color transition when added to ethanol and could be quickly separated from solution with a common magnet. Surface functionalization of the particles with bovine serum albumin (BSA) showed the ability to capture and detect anti-BSA antibody from antiserum with a colorimetric response, demonstrating our biosensors can serve as a platform for diagnostic applications including point-of-care testing. (C) 2013 Elsevier B.V. All rights reserved.
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