Journal
BIOSENSORS & BIOELECTRONICS
Volume 43, Issue -, Pages 379-383Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2012.12.056
Keywords
Biosensor; Copper ion; Molecular beacon; Graphene oxide; Fluorescence
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Funding
- Research Grants Council of the Hong Kong Special Administrative Region [615710]
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In this work, we report a turn-on fluorescent strategy for the direct detection of Cu2+ in solutions using molecular beacons (MBs) and graphene oxide (GO). MBs are special single-stranded DNA and carry fluorescence sources. GO is a new nanomaterial having remarkable physical properties. In the sensing system, GO was used as an efficient fluorescence quencher upon the adsorption of MBs, which reduced the background signal and made the detection method highly sensitive. In the presence of Cu2+, the MBs were cut into short pieces and released by the GO, leading to fluorescence restoration. The detection limit of the sensing strategy was similar to 50 nM, which is sufficiently sensitive for practical applications. The sensing method also exhibited high selectivity in testing samples containing other metal ions. The application of the method for drinking water is demonstrated. (C) 2013 Elsevier B.V. All rights reserved.
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