Journal
BIOSENSORS & BIOELECTRONICS
Volume 49, Issue -, Pages 199-203Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2013.04.022
Keywords
Dopamine; Functionalized AuNPs; Doping; Molecularly imprinted polymers; Electrochemical sensor
Categories
Funding
- National Natural Science Foundation of China [1273480, 21175070, 81202853]
- Natural Science Foundation of Jiangsu Education Committee [10KJB150011]
- Natural Science Foundation of Jiangsu Province [BK2012444]
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In this work, a highly sensitive and selective biomimetic electrochemical sensor for the amperometric detection of trace dopamine (DA) in human serums was achieved by gold nanoparticles (AuNPs) doped molecularly imprinted polymers (MIPs). Functionalized AuNPs (F-AuNPs), a novel functional monomer bearing aniline moieties on the surface of the AuNPs, were prepared via a direct synthesis method and then used to fabricate the conductive MIPs film on the modified electrode by electropolymerization method in the presence of DA and p-aminobenzenethiol (p-ATP). The obtained electrochemical sensor based on the conductive film of AuNPs doped MIPs (AuNPs@MIPs) could effectively minimize the interferences caused by ascorbic acid (AA) and uric acid (UA). The linear range for amperometric detection of DA was from 0.02 mu mol L-1 to 0.54 mu mol L-1 with the detection limit of 7.8 nmol L-1 (S/N=3). Furthermore, the AuNPs@MIPs modified electrode (AuNPs@MIES) was successfully employed to detect trace DA in different human serums. (C) 2013 Elsevier B.V. All rights reserved.
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