Journal
BIOSENSORS & BIOELECTRONICS
Volume 41, Issue -, Pages 249-255Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2012.08.031
Keywords
Localized surface plasmon resonance; Nanoislands; Adenovirus; Rigorous coupled-wave analysis; Transfer matrix method; Target-field overlap
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Funding
- National Research Foundation (NRF)
- Korean Government [2009-0070732, 2010-0007993, 2011-0017500]
- National Research Foundation of Korea [2009-0070732] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In this paper, we investigate localized surface plasmon resonance (SPR) detection based on nanoislands. Theoretical calculation performed with rigorous coupled-wave analysis and analytical transfer matrix method using effective medium theory suggests improvement on nanoislands in the limit of detection and sensitivity over conventional thin film-based SPR detection. Experimental results obtained with non-specific detection of ambient adenovirus confirm the improvement by more than one order of magnitude increase in the limit of detection. The enhancement achieved with nanoislands was explored in connection with efficient overlap between target and near-field distribution produced by nanoislands. (C) 2012 Elsevier B.V. All rights reserved.
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