Journal
BIOSENSORS & BIOELECTRONICS
Volume 49, Issue -, Pages 457-461Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2013.06.006
Keywords
Sensitivity amplification; BPA detection; Food safety; Lateral flow strip
Categories
Funding
- Huangshan Young Scholar Fund of Hefei University of Technology [407-037025]
- Science and Technology Research Project of General Administration of Quality Supervision, Inspection and Quarantine of P. R. China [201210127, 201310135]
- 12th Five Years Key Programs [2012BAK08B01-2, 2012BAK17B10, SS2012AA101001]
- Fundamental Research Funds for the Central Universities [2013HGCH0008, 2012HGCX0003]
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A one-step signal amplified lateral flow strip (LFS) biosensor has been developed for ultrasensitive and on-site visual detection of bisphenol A (BPA). This signal amplified LFS was based on the dual labeling using different-sized gold nanoparticles (Duo-LFS). This Duo-LFS could achieve BPA detection with 0.5 ng/mL as the visual sensitivity by naked eye observation and with 0.076 ng/mL as the limit of detection (LOD) for semi-quantitative detection by software analysis, which is at least 10-fold improvement of the sensitivity of traditional LFS based methods. This one-step signal amplified lateral flow strip biosensor and related signal enhancement method could be adopted as a potential generous technique for all LFS-based detection methods. Crown Copyright (C) 2013 Published by Elsevier B.V. All rights reserved.
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