Journal
BIOSENSORS & BIOELECTRONICS
Volume 49, Issue -, Pages 164-169Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2013.05.007
Keywords
Conducting polymer; Square wave voltammetry; Oligonucleotides; Electrochemical biosensor; Label-free detection; MicroRNA
Categories
Funding
- University of Sciences and Technology of Hanoi (USTH)
- University Paris Diderot
Ask authors/readers for more resources
In this paper, a label-free and reagentless microRNA sensor based on an interpenetrated network of carbon nanotubes and electroactive polymer is described. The nanostructured polymer film presents very well-defined electroactivity in neutral aqueous medium in the cathodic potential domain from the quinone group embedded in the polymer backbone. Addition of microRNA miR-141 target (prostate cancer biomarker) gives a signal-on response, i.e. a current increase due to enhancement of the polymer electroactivity. On the contrary, non-complementary miRNAs such as miR-103 and miR-29b-1 do not lead to any significant current change. A very low detection limit of ca. 8 fM is achieved with this sensor. (C) 2013 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available