Journal
BIOSENSORS & BIOELECTRONICS
Volume 50, Issue -, Pages 362-367Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2013.06.034
Keywords
Biosensor; Biomolecule; Radio-frequency; Surface acoustic wave filter; Wireless sensor node
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Funding
- National Research Foundation of Korea (NRF)
- Ministry of Education [2013R1A1A2A10009871]
- Yonsei University
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In this paper, we propose a radio-frequency (RF) biosensor platform based on oscillation frequency deviation at 2.4 GHz. Its feasibility is experimentally demonstrated with the well-known biomolecular binding systems such as biotin-streptavidin and deoxyribonucleic acid (DNA) hybridization. For a basic principle of our biosensing system, the impedance of a resonator with the biomolecular immobilization is at first varied so that the corresponding change results in frequency change of an oscillator. Especially, to enhance the sensitivity of the proposed system, a surface acoustic wave (SAW) filter having a high-Q factor (similar to 2000) is utilized. From the resulting component, even a small change of oscillation frequency can be transformed into a large output amplitude variation. According to the experimental results, it is found that our system shows the low detectable limit (similar to 1 ng/ml) and fast response time (similar to real-time) for different target biomolecules, i.e. streptavidin and complementary DNA (cDNA). As a result, we find that our device is an effective biosensing system that can be used for a label-free and real-time measurement of the biomolecular binding events. (C) 2013 Published by Elsevier B.V.
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