Journal
BIOSENSORS & BIOELECTRONICS
Volume 43, Issue -, Pages 186-192Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2012.12.007
Keywords
Taste epithelium; Microelectrode array (MEA); Taste sensor; Multi-channel analysis; Principal component analysis (PCA)
Categories
Funding
- National Natural Science Foundation of China [81027003, 81071226]
- Research on Public Welfare Technology Application Projects of Zhejiang Province, China [2011C23096]
- Fundamental Research Funds for the Central Universities
Ask authors/readers for more resources
Taste receptor cells in taste buds can generate action potentials in response to taste stimuli. The spatiotemporal patterns of the potentials have great value in both biomedical and engineering researches. In the present study, by fixing the biological epithelium onto the surface of microelectrode arrays (MEA), we established a novel taste sensor to record action potentials from the taste receptor cells of rat in response to taste stimuli. By this multi-channel recording method, we examined the electrophysiological activities of taste receptor cells in taste buds to stimuli representing the basic taste qualities (sour, salt, bitter, sweet and umami). The recorded action potentials corresponding to five tastes displayed different spatiotemporal patterns. The multi-channel results demonstrated that taste buds released the spontaneous signals simultaneously and displayed different responses to different tastes stimulations. The temporal characteristics were derived by time-domain and frequency-domain analysis, and the signals fired in different stimuli could be distinguished into different clusters by principal component analysis (PCA). The study provides an effective and reliable platform to recognize and distinguish basic taste qualities. (c) 2012 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available