Journal
EXPERIMENTAL AND MOLECULAR MEDICINE
Volume 50, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/emm.2017.223
Keywords
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Funding
- Major State Basic Research Development Program of China [2013CB531503]
- National Foundation of China [81502728]
- Anhui Provincial Natural Science Foundation [1408085MH149]
- Research Program of Foundation Science and Application Technology of Chongqing [cstc2015jcyjA10105, cstc2015jcyjA10119]
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The expression or dysfunction of long non-coding RNAs (lncRNAs) is closely related to various hereditary diseases, autoimmune diseases, metabolic diseases and tumors. LncRNAs were also recently recognized as functional regulators of fibrosis, which is a secondary process in many of these diseases and a primary pathology in fibrosis diseases. We review the latest findings on lncRNAs in fibrosis diseases of the liver, myocardium, kidney, lung and peritoneum. We also discuss the potential of disease-related lncRNAs as therapeutic targets for the clinical treatment of human fibrosis diseases.
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