Journal
BIOSENSORS & BIOELECTRONICS
Volume 26, Issue 9, Pages 3881-3886Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2011.03.002
Keywords
Graphene; Reduced graphene oxide; Impedance spectroscopy; Methicillin-resistant Staphylococcus aureus; DNA; Label-free detection
Categories
Funding
- AcRF Tier 2, MOE [ARC 10/10, MOE2010-T2-1-060]
- POC, EDB [S08/1-82563404]
- CRP, NRF [NRF-CRP2-2007-01]
- A*STAR [092 101 0064]
- NTU [M58120031]
- Centre for Biomimetic Sensor Science at NTU in Singapore
- A*STAR in Singapore [072 101 0020]
- Swedish Research Council
- Foundation for Strategic Research
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Reduced graphene oxide (rGO)-modified glassy carbon electrode is used to detect the methicillin-resistant Staphylococcus aureus (MRSA) DNA by using electrochemical impedance spectroscopy. Our experiments confirm that ssDNA, before and after hybridization with target DNA, are successfully anchored on the rGO surface. After the probe DNA, pre-adsorbed on rGO electrode, hybridizes with target DNA, the measured impedance increases dramatically. It provides a new method to detect DNA with high sensitivity (10(-13)M, i.e., 100 fM) and selectivity. (C) 2011 Elsevier B.V. All rights reserved.
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