Journal
AUTOPHAGY
Volume 14, Issue 2, Pages 207-215Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2017.1378838
Keywords
ATG proteins; autophagic lysosome reformation; omegasome; phagophore; RAB protein; SNARE
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Funding
- Francis Crick Institute from Cancer Research UK [FC001187]
- UK Medical Research Council [FC001187]
- Wellcome Trust [FC001187]
- Ministry of Science and Technology of the People's Republic of China [2016YFA0500202, 2015BAI08B01]
- National Natural Science Foundation of China [31671395, 31430053, 31321003]
- Cancer Research UK [15153] Funding Source: researchfish
- The Francis Crick Institute [10187] Funding Source: researchfish
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Macroautophagy/autophagy is an essential, conserved self-eating process that cells perform to allow degradation of intracellular components, including soluble proteins, aggregated proteins, organelles, macromolecular complexes, and foreign bodies. The process requires formation of a double-membrane structure containing the sequestered cytoplasmic material, the autophagosome, that ultimately fuses with the lysosome. This review will define this process and the cellular pathways required, from the formation of the double membrane to the fusion with lysosomes in molecular terms, and in particular highlight the recent progress in our understanding of this complex process.
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