Journal
BIOSENSORS & BIOELECTRONICS
Volume 28, Issue 1, Pages 428-433Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2011.07.061
Keywords
Ricin; Carbon nanofiber; Antibody; Aptamer; Electrochemical impedance spectroscopy
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Funding
- Texas Southern University
- Norfolk State University
- NASA URC [NNX08BA47A]
- Department of Homeland Security [IAA: HSHQDC-08-X-00870]
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We report ricin detection using antibody and aptamer probes immobilized on a nanoelectrode array (NEA) consisting of vertically aligned carbon nanofibers (VACNFs). These biosensor chips are fabricated on a wafer scale using steps common in integrated circuit manufacturing. Electrochemical impedance spectroscopy is used to characterize the detection event and the results indicate that the electron transfer resistance changes significantly after the ricin protein binds to the probe. Further confirmation is obtained from evaluation of the electrode surface by atomic force microscopy which clearly shows a change in height from the bare electrode to the surface bound by the probe-protein. Published by Elsevier B.V.
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