Journal
BIOSENSORS & BIOELECTRONICS
Volume 26, Issue 5, Pages 2746-2750Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2010.09.059
Keywords
Silicon nanowires; Nanoelectronic biosensing; Biosensors; Inflammatory cytokines; Bio-nanotechnology; Immune response
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Funding
- Science and Engineering Research Council of A*STAR [072 101 0020]
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Nanotechnology, such as nanoelectronic biosensors, is bringing new opportunities and tools to the studies of cell biology, clinical applications, and drug discovery. In this study, cyrstalline silicon nanowire based field-effect transistors fabricated using top-down approach were employed to parallelly detect pro-inflammatory cytokines in the complex biological fluids (cell culture medium and blood samples) with high specificity and femtomolar sensitivity. Using this technique, the dynamic secretion of TNFalpha and IL6 was revealed during the immune response of macrophages and rats to the stimulation of bacteria endotoxin. This technique could provide a unique platform to examine the profile of complex immune responses for fundamental studies and diagnosis. (c) 2010 Elsevier B.V. All rights reserved.
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