Journal
BIOSENSORS & BIOELECTRONICS
Volume 26, Issue 5, Pages 1815-1824Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2010.09.030
Keywords
Surface plasmon resonance; SPR imaging; Optical sensor; Biochip design; Biosensor; Label-free detection
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Funding
- US National Science Foundation [CHE-0719224]
- National Institute of Health [1R21EB-009551]
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Surface plasmon resonance (SPR)-based biosensing is one of the most advanced label free, real time detection technologies. Numerous research groups with divergent scientific backgrounds have investigated the application of SPR biosensors and studied the fundamental aspects of surface plasmon polaritons that led to new, related instrumentation. As a result, this field continues to be at the forefront of evolving sensing technology. This review emphasizes the new developments in the field of SPR-related instrumentation including optical platforms, chips design, nanoscale approach and new materials. The current tendencies in SPR-based biosensing are identified and the future direction of SPR biosensor technology is broadly discussed. (C) 2010 Elsevier B.V. All rights reserved.
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