Journal
BIOSENSORS & BIOELECTRONICS
Volume 27, Issue 1, Pages 12-17Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2011.03.010
Keywords
Cell based biosensor; Olfactory sensor; Spatiotemporal patterning; Olfactory epithelium; Microelectrode array (MEA)
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Funding
- National Natural Science Foundation of China [81071226, 60725102]
- Zhejiang Provincial Natural Science Foundation of China [Y2100684, Y2111065]
- Education Department of Zhejiang Province, China [Y200909323]
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In olfactory biosensors, microelectronic sensor chips combined with biological olfactory cells are a promising platform for odor detection. In our investigation, olfactory epithelium stripped from rat was fixed on the surface of microelectrode arrays (MEAs). Electrophysiological activities of olfactory receptor neurons in intact epithelium were measured in the form of extracellular potentials. Based on multichannel recording performance of MEA and structural and functional integrality of native olfactory epithelium, the spatiotemporal analysis was carried out to study the extracellular activity pattern of neurons in the tissue. The variation of spatiotemporal patterns corresponding to different odors displayed the signals firing image characteristic intuitionally. It is an effective method in the form of patterns for monitoring the state of tissue both in time and space domain, promoting the platform for olfactory sensing mechanism research. (C) 2011 Elsevier B.V. All rights reserved.
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