Journal
BIOSENSORS & BIOELECTRONICS
Volume 26, Issue 5, Pages 2737-2741Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2010.09.051
Keywords
Photoelectrochemistry; Chemiluminescence; DNA biosensor; Ru(bpY)(2)dppz(2+)
Categories
Funding
- National Natural Science Foundation [20905040, 20827005]
- Natural Science Foundation of Shandong Province [Y2008832]
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Physical light source is absolutely necessary for usual photoelectrochemical measurement. In this work, chemiluminescence reaction rather than physical light source was used for the development of a novel photoelectrochemical DNA biosensor. CIPO (bis(2,4,5-trichlro-6-n-pentoxycarbonylphenyl)oxalate)-H2O2-9,10-diPhenylanthrancene was selected as a CL system, which can produce appropriate exciting light and excite photoelectro active materials Ru(bpy)(2)dppz(2+) intercalated into the double-stranded DNA. Using such simple intercalation method, a detection limit of 4.5 x 10(-9) M target DNA was achieved without any amplification process. In addition, the selected CL system could be used to excite AuNPs-Ru(bpy)(2)dppz(2+) complex as well as CdSe QD multilayer, which indicated a good applicability for the established method. (c) 2010 Elsevier B.V. All rights reserved.
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