Journal
BIOSENSORS & BIOELECTRONICS
Volume 26, Issue 11, Pages 4514-4519Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2011.05.012
Keywords
Au nanospheres; Nanorods; Biosensors; Electrocatalyst; Enzyme-free
Categories
Funding
- NSF [0804464, 0728130]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [0804464] Funding Source: National Science Foundation
- Office Of Internatl Science &Engineering
- Office Of The Director [0728130] Funding Source: National Science Foundation
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Au nanocrystals with different morphologies were prepared and used for enzyme-free electrochemical biosensor applications. To investigate the electrocatalytic properties of Au nanocrystals as a function on their morphologies, Au nanocrystals, Au nanospheres (NSs) on silica, Au NSs, and Au nanorods (NRs) with aspect ratios of 1:3 and 1:5, were coated on the screen printed electrodes and further measure the amperometic responses to hydrogen peroxide via three-electrode system. The electrodes modified with Au nanocrystals showed biosensing properties without any enzyme being attached or immobilized at their surface. The hydrogen peroxide detection limits of the biosensors with Au NSs, Au NRs (1:3), and Au NRs (1:5) were 6.48, 8.65, and 9.38 mu M (S/N = 3), respectively. The biosensors with Au NSs, Au NRs (1:3), and Au NRs (1:5) showed the sensitivities of 11.13, 54.53, and 58.51 mu A/mM, respectively. These results indicate that morphologies of Au nanocrystals significantly influence the sensitivity of the biosensors. In addition, the enzyme-free biosensors with Au nanocrystals were stable for 2 months. Au nanocrystal-based enzyme-free system, which is proposed in this study, can be used as a platform for various electrochemical biosensors. (C) 2011 Elsevier B.V. All rights reserved.
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