Journal
BIOSENSORS & BIOELECTRONICS
Volume 26, Issue 7, Pages 3246-3253Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2010.12.034
Keywords
Giant magnetoimpedance; Gastric cancer cell; Targeted detection; Biosensing system; Prototype
Categories
Funding
- Chinese 973 Project [2010CB933901]
- 863 Key Project [2007AA022004]
- Science & Technology Committee of Shanghai [09JC1408600]
- Shanghai Science and Technology Fund [10XD1406100, 1052nm04100]
- No-Silicon Precision Micro-maching & Microfabrication Technology [D2320060098]
- State Key Development Program of Basic Research of China [2010CB933901]
- National Natural Science Foundation of China [20803040, 61074168]
- New Century Excellent Talent of Ministry of Education of China [NCET-08-0350]
- Special Infection Diseases Key Project of China [2009ZX10004-311]
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A targeted detection of gastric cancer cells is achieved by combining the giant magnetoimpedance (GMI)-based biosensing system and RGD-4C peptide coupled, chitosan covered superparamagnetic iron oxide particles (RGD-Fe3O4@chitosan). The micro-patterned GMI sensor for targeted detection is made of Co-based ribbon and fabricated by micro electromechanical system (MEMS) technology. Functionalized nanoparticles were designed by coating Fe3O4 with chitosan and conjugating with RGD-4C peptides. The targeted cells were trickled down into the detection area of the system. The detection of each sample is carried out in ten-fold manner and average value is taken as the final result. This system can identify the differences between targeted cells and non-targeted cells. It is of considerable interest due to its potential application in the biomedical field of various specific detections. (C) 2010 Elsevier B.V. All rights reserved.
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