Journal
BIOSENSORS & BIOELECTRONICS
Volume 26, Issue 5, Pages 2413-2418Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2010.10.022
Keywords
Biosensor; Surface enhanced Raman spectroscopy; DNA; Surface plasmon; Nanostructure
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Funding
- National Science Council, Taiwan
- Air Force Office of Scientific Research, USA
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Label free optical sensing of adenine and thymine oligonucleotides has been achieved at the sub-picomole level using self assembled silver nanoparticles (AgNPs) decorated gold nanotip (AuNT) arrays. The platform consisting of the AuNTs not only aids in efficient bio-immobilization, but also packs AgNPs in a three dimensional high surface area workspace, assisting in surface enhanced Raman scattering (SERS). The use of sub-10 nm AgNPs with optimum inter-particle distance ensures amplification of the chemically specific Raman signals of the adsorbed adenine, thymine, cytosine and guanine molecules in SERS experiments. High temporal stability of the Raman signals ensured reliable and repeatable DNA detection even after three weeks of ambient desk-top conservation. This facile architecture, being three dimensional and non-lithographic, differs from conventional SERS platforms. (C) 2010 Elsevier B.V. All rights reserved.
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