Journal
BIOSENSORS & BIOELECTRONICS
Volume 30, Issue 1, Pages 140-144Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2011.09.001
Keywords
Microcantilever; Trimethylamine; Biosensor
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Funding
- National Institutes of Health (NIH) [1R01NS057366]
- National Natural Science Foundation of China (NSFC) [20728506/B05]
- Important National Science & Technology Specific Projects [2011ZX08012-001, 2009ZX08012-001B, 2009ZX08015-003A]
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We report a biosensor based on a microcantilever that is modified by a specific peptide for highly selective detection of trimethylamine (TMA). The assay is based on binding-induced bending of the peptide functionalized microcantilevers. The sensor is selectively responsive to TMA. The amplitude of microcantilever bending at equilibrium is a function of the concentration of TMA with a dynamic range from 8 ppm to 800 ppm. The detection limit is approximately 8 ppm. There is a good intra-sensor and an acceptable inter-sensor reproducibility as evidenced by the standard deviation of 5% and 15%, respectively. (C) 2011 Elsevier B.V. All rights reserved.
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