Journal
BIOSENSORS & BIOELECTRONICS
Volume 25, Issue 10, Pages 2366-2369Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2010.02.031
Keywords
Dopamine; Ascorbic acid; Graphene; Cyclic voltammetry; Electrochemical impedance spectroscopy
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Funding
- Korean Government (MEST) [R11-2005-008-06002-0]
- CRI [20090081566]
- Brain Korea 21 fellowship
- Korean Federation of Science and Technology Societies (KOFST) [082S-1-3-0195]
- National Research Foundation of Korea [082S-1-3-0195, 2009-0081566] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Dopamine plays a significant role in the function of human metabolism. It is important to develop sensitive sensor for the determination of dopamine without the interference by ascorbic acid. This paper reports the synthesis of graphene using a modified Hummer's method and its application for the electrochemical detection of dopamine. Electrochemical measurements were performed at glassy carbon electrode modified with graphene via drop-casting method. Cyclic voltammogram of ferri/ferrocyanide redox couple at graphene modified electrode showed an increased current intensity compared with glassy carbon electrode and graphite modified electrode. The decrease of charge transfer resistance was also analyzed by electrochemical impedance spectroscopy. The capacity of graphene modified electrode for selective detection of dopamine was confirmed in a sufficient amount of ascorbic acid (1 mM). The observed linear range for the determination of dopamine concentration was from 4 mu M to 100 mu M. The detection limit was estimated to be 2.64 mu M. (C) 2010 Elsevier BM. All rights reserved.
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