Journal
BIOSENSORS & BIOELECTRONICS
Volume 26, Issue 2, Pages 809-814Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2010.06.018
Keywords
Molecularly imprinted polymer; Surface-enhanced Raman scattering; Nano-fountain pen
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Funding
- European Union [QLK4-CT2002-02323]
- Marie Curie Research Training Network [MRTN-CT-2006-33873]
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Writing a molecularly imprinted polymer (MIP) by nano-fountain pen on surface-enhanced Raman scattering (SERS)-active surfaces resulted in site-controlled arrays of microdots of approximately 6-12 mu m in diameter. The monitoring of SERS spectra with a micro-Raman system enabled examining the uptake and release of the S-propranolol imprinting template and allowed imaging individual dots as well as multiple dots in an array, revealing the distribution of the imprinted polymer. This distribution was confirmed by atomic force microscopy, showing that even in dots of <300 nm thickness, corresponding to MIP volumes of 0.5 fl, significantly less than previously reported, the target analyte could be detected and identified. This study shows that nanolithography techniques combined with SERS might open the possibility of miniaturized arrayed MIP sensors with label-free, specific and quantitative detection. (C) 2010 Elsevier B.V. All rights reserved.
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