Journal
NATURE CATALYSIS
Volume 1, Issue 6, Pages 469-478Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41929-018-0080-y
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Funding
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
- Natural Science Foundation of Fujian [2017J06007, 2017J05038]
- NSFC [21702206, 21402198]
- 100 Talents Program of Fujian Province
- National 1000 Youth Talents Program
- State Key Laboratory of Structural Chemistry
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Although carbon dioxide (CO2) is an attractive renewable carbon source, its utilization to produce fine chemicals through the catalytic carboxylation of unactivated carbon-hydrogen (C-H) bonds is still very limited and remains a challenge, largely because CO2 is thermodynamically and kinetically stable. In particular, the generation of (hetero)aromatic carboxylic acids via a transition-metal-catalysed C-H carboxylation of arenes with CO2 is extremely rare. Here we report a ligand-enabled site-selective carboxylation of 2-arylphenols under atmospheric pressure of CO2 through a Rh-2(OAc)(4)-catalysed and chelation-assisted C-H bond activation. Remarkably, the reaction occurs selectively on the less nucleophilic phenyl group with the promotion of a phosphine ligand, which overrides the site selectivity dictated by the well-known Kolbe-Schmitt type reaction. The non-acidic C-H bonds within several important classes of heterocycles were also efficiently carboxylated with this method. A mechanistic investigation revealed complexes of active catalysts and that this reaction proceeds under redox-neutral reaction conditions.
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