Journal
BIOSENSORS & BIOELECTRONICS
Volume 24, Issue 7, Pages 2260-2263Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2008.10.018
Keywords
Hollow gold nanosphere; Surface-enhanced Raman scattering; Cellular imaging; Cancer marker; Homogeneous sensing probe
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Funding
- Korea Science and Engineering Foundation [R01-2007-000-20238-0, R11-2008-044-01002-0]
- National Cancer Center of Korea [0620400-1]
- Seoul Research and Business Development Program [10574]
- Korea Health Promotion Institute [0620400] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [R11-2008-044-01002-0, R01-2007-000-20238-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Anti body-conjugated hollow gold nanospheres (HGNs) have been used for the SERS imaging of HER2 cancer markers overexpressed in single MCF7 cells. SERS mapping images show that HGNs have much better homogeneous scattering properties than silver nanoparticles. The results demonstrate the potential feasibility of HGNs as highly sensitive and homogeneous sensing probes for biological imaging of cancer markers in live cells. (C) 2008 Elsevier B.V. All rights reserved.
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