Journal
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
Volume 6, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2018.00008
Keywords
RNA pseudouridylation; steroid receptor RNA activator; 7SK RNA; spliceosomal small nuclear RNA; transcription; pre-mRNA splicing
Funding
- NIH [GM104077]
- Vanderbilt University Medical Center
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM104077] Funding Source: NIH RePORTER
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Pseudouridine is the most abundant internal RNA modification in stable noncoding RNAs (ncRNAs). It can be catalyzed by both RNA-dependent and RNA-independent mechanisms. Pseudouridylation impacts both the biochemical and biophysical properties of RNAs and thus influences RNA-mediated cellular processes. The investigation of nuclear-ncRNA pseudouridylation has demonstrated that it is critical for the proper control of multiple stages of gene expression regulation. Here, we review how nuclear-ncRNA pseudouridylation contributes to transcriptional regulation and pre-mRNA splicing.
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